Rifampicin markedly decreases the exposure to oral and intravenous tramadol

Tuukka Saarikoski,Teijo I. Saari,Nora M. Hagelberg,Mikko Neuvonen,Pertti J. Neuvonen,Mika Scheinin,Klaus T. Olkkola,Kari Laine

Rifampicin markedly decreases the exposure to oral and intravenous tramadol

2013

Tuukka Saarikoski
Teijo I. Saari
Nora M. Hagelberg
Mikko Neuvonen
Pertti J. Neuvonen
Mika Scheinin
Klaus T. Olkkola
Kari Laine

Purpose Tramadol is mainly metabolized by the cytochrome P450 (CYP) 2D6, CYP2B6 and CYP3A4 enzymes. The aim of this study was to evaluate the effect of enzyme induction with rifampicin on the pharmacokinetics and pharmacodynamics of oral and intravenous tramadol.

Keywords:

Anesthesia
Enzyme inducer
CYP2B6
Cytochrome P-450 CYP2D6
Medicine
Tramadol
Pharmacology
CYP3A4
Rifampicin
O-Desmethyltramadol
Pharmacokinetics

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