THREE YEARS APPLICATION OF SELECTIVE DIGESTIVE DECONTAMINATION IN A MIXED INTENSIVE CARE UNIT IN A UNIVERSITY HOSPITAL: IMPACT ON COLONIZATION, INFECTION AND ANTIBIOTIC CONSUMPTION

Methods This study was conducted in a 30-bed-medical-surgical ICU. All consecutive patients admitted to the from October 1, 2011 to September 30, 2014 expected to require tracheal intubation for longer than 48 hours were given SDD (SDD study group) with a 4-day course of intravenous cefotaxime, plus enteral colistin, tobramycin, nystatin in an oropharyngeal paste and in a digestive solution. Oropharyngeal and rectal swabs were obtained on admission and once weekly. Nosocomial infections were diagnosed by CDC criteria. We compared all patients admitted to ICU who acquired nosocomial ICU colonization and infection from October 1, 2010 to September 30, 2011 (non-SDD group) to SDD group. In both groups, categorical variables were summarized as frequencies and percentages and the continuous ones as means and standard deviations when the data followed the normal distribution or medians and interquartile ranges when they did not. The percentages were compared using the test of chisquare test or Fisher exact test, means with the t-test and medians with the Wilcoxon test for independent samples. Those variables that showed statistical significance in the univariate analysis were introduced in a multivariate logistic regression analysis. For each one of the acquired infections (catheter-related and other secondary bacteremias, pneumonia and urinary infections and antibiotic resistant bacteria (ARB) infection) the incidences per 1000 days of exposure in each cohort and the corresponding relative risks were obtained using the Poisson regression. Statistical significance was set at p ≤ 0.05. We also analized colistin and tobramycin resistant colonization and antibiotic consumption (Defined Antibiotics daily Doses (DDD)).