Midterm and Long-Term Impacts of GnRH Agonists Treatments

GnRH analogs treatment is effective on final height, especially when treatment is started before the age of 6 years old.On average, the BMI of girls with precocious puberty treated with GnRH analogs is higher than the BMI of girls from the general population. However, large variability is reported in the literature.GnRH analogs treatment does not seem to alter final postpubertal bone maturation.GnRH analogs treatment does not seem to alter fertility of men and women treated during their infancy.Few data have been reported concerning psychological evaluations of children treated during their infancy by GnRH analog treatment for precocious puberty.