SPARC Production by Bone Marrow-Derived Cells Contributes to Myocardial Fibrosis in Pressure-Overload.

Hannah J. Riley,Ryan R. Kelly,An O. Van Laer,Lily S Neff,Shaoni Dasgupta,Catalin F. Baicu,Lindsay T. McDonald,Amanda C. LaRue,Michael R. Zile,Amy D. Bradshaw

SPARC Production by Bone Marrow-Derived Cells Contributes to Myocardial Fibrosis in Pressure-Overload.

2020

Hannah J. Riley
Ryan R. Kelly
An O. Van Laer
Lily S Neff
Shaoni Dasgupta
Catalin F. Baicu
Lindsay T. McDonald
Amanda C. LaRue
Michael R. Zile
Amy D. Bradshaw

In human heart failure and in murine hearts with left ventricular pressure overload (LVPO), increases in fibrosis are associated with increases in stiffness. Secreted Protein Acidic and Rich in Cys...

Keywords:

Ventricular pressure
Cardiology
Bone marrow
Extracellular matrix
myocardial fibrosis
Inflammation
human heart
Internal medicine
Pressure overload
Fibrosis
Medicine

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