Changes in oxidative phosphorylation in rat liver mitochondria during the development of cholestasis

Kinetic patterns of oxydative phosphorylation were studied in rat liver mitochondria in dynamics of cholestasis and after addition of bile acids to mitochondria in vitro. Within the 1 and 3 days of cholestasis mitochondrial synthesis of ATP was decreased due to inhibition of ATP and ADP transport by the bile acids. At the period within 3 and 15 days uncoupling of the oxidative phosphorylation occurred; the phenomenon observed might be a result of impairment in the structure of inner mitochondrial membrane.