NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

Dysregulated inflammasome activation is associated with auto-inflammatory diseases. Chadee and colleagues show that prostaglandin E2 triggers rapid inhibition of the inflammasome component NLRP3 by the kinase PKA. Patients with the inflammatory disease CAPS who have mutations in NLPR3 escape this negative regulation.