Effects of estrogen on expression of choline acetyltransferase and nitric oxide synthase 1 in intracardiac ganglionic neurons in ovariectomized rats

The ChAT and NOS_(1) levels in the OVX group was evidently lower than those in the normal group, and there was no evident difference between the ERT group and the normal group, but the ChAT and NOS_(1) levels in the OVX+TAM+E2 group were lower than those in the normal group. There was no evident difference between the OVX group and the OVX+TAM+E2 group. The results suggest that estrogen can upregulate the expression of ChAT and NOS_(1) in the intracardiac ganglionic neurons of the rats, and then indirectly regulates the function of the cardiovascular system.