RENAL ADENOCARCINOMA METASTASIS IN ORAL SOFT TISSUES: A CASE REPORT

Oral cavity metastases are rare events and occur mainly in the jaws compared with the soft tissues. A 69-year-old Caucasian woman was referred to the stomatology service complaining of a bleeding oral lesion, which developed 4 months before the appointment. The patient had a renal adenocarcinoma, which was treated with right radical nephrectomy and chemotherapy. Immunotherapy with nivolumab was started 1 month before the lesion appearance. On examination, we observed an erythematous, pediculated mass, about 1.5 cm in diameter, with ulcerative surface on the right buccal mucosa. An incisional biopsy was performed, and the microscopic exam revealed the presence of clear epithelial cells and intense vascular neoformation. Immunohistochemical analysis was positive for cytokeratins AE1 and AE3 and PAX8, confirming the diagnosis of metastatic clear cell from the renal adenocarcinoma. The patient died in the same year, as the result of the disease progression.