The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.

Di Zhu,Zhongqiu Wang,Jian Jun Zhao,Teresa Calimeri,Jiang Meng,Teru Hideshima,Mariateresa Fulciniti,Yue Kang,Scott B. Ficarro,Yu-Tzu Tai,Zachary R. Hunter,Douglas McMilin,Haoxuan Tong,Constantine S. Mitsiades,Catherine J. Wu,Steven P. Treon,David M. Dorfman,Geraldine S. Pinkus,Nikhil C. Munshi,Pierfrancesco Tassone,Jarrod A. Marto,Kenneth C. Anderson,Ruben D. Carrasco

The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.

2015

Cyclophilin A, secreted by bone marrow endothelial cells, acts as a chemotactic factor for myeloma cells, which helps explain their homing to the bone marrow and suggests a potential new therapeutic strategy.

Keywords:

Immunology
Chemotaxis
Virology
Bone marrow
Beta-catenin
Wnt signaling pathway
Cyclophilin A
Cell growth
Biology
Homing (biology)
Multiple myeloma
Transcription factor

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