İntravenöz Deksmedetomidin Premedikasyonunun Bupivakain ile Uygulanan Spinal Anestezide Duyusal Blok Süresine Etkisi

-1 (Grup D, n=25), midazolam 0.05 mg kg -1 (Grup M, n=25) veya serum fizyolojik (Grup K, n=25) uygulamasindan sonra, sedasyon seviyesi, duyusal blok ust seviyesi, duyusal ve motor blok gerileme zamani kaydedildi. Ramsay sedasyon skoru, Grup D ve Grup M'de benzer ve Grup K'den daha yuksek bulundu (her iki grup icin p<0.001). Duyusal blok ust seviyesi, Grup D'de, Grup M ve Grup K'ye gore daha yuksek olarak saptandi (her iki grup icin p<0.001). Deksmedetomidin grubunda duyusal blok suresinin, midazolam ve kontrol grubundan daha uzun oldugu, ancak motor blok suresini uzatmadigi belirlendi (her iki grup icin p<0.05). Postoperatif ilk analjezik gereksinim zamani, Grup D'de Grup M ve K'ye gore daha uzun bulundu (her iki grup icin p<0.01). Postoperatif analjezik tuketimi Grup D'de, Grup M ve Grup K'ye gore daha azdi (her iki grup icin p<0.05). Deksmedetomidin ile premedikasyon midazolama benzer sedasyon ve daha belirgin analjezi saglar. Ek olarak, deksmedetomidin bupivakain ile uygulanan spinal anestezinin duyusal blok suresini uzatir. In this double blind, randomized and placebo-controlled study, we aimed to compare the effects of dexmedetomidine and midazolam on the sensory or motor blockage, following a single dose administration, before spinal anesthesia. Seventy-five ASA I-II patients undergoing transurethral resection of the prostate (TUR-P) either received intravenous dexmedetomidine 0.5 µg kg -1 (Group D, n = 25) or midazolam 0.05 mg kg -1 (Group M, n = 25) or saline (Group K, n = 25) 5 minutes prior to spinal anesthesia were enrolled.Level of sedation, upper level of sensory blockage and the time of sensory and motor blockage regression were then recorded. The Ramsay sedation scores were detected to be similar in Group D and Group M both of which were higher than those in the Group K (p<0.001 for two groups). The upper sensory blockage level was revealed to be higher in Group D compared to Group M or Group K (p<0.001 for two groups). The duration of the sen- sory blockage in the dexmedetomidine group was detected to be longer than the midazolam or saline group, but not the duration of motor block (p<0.05 for two groups). It was found in Group D that the postoperative first analgesic necessity time was longer than Group M or Group K (p<0.01 for two groups). Postoperative analgesic consumption were less in the group D compared with groups M and P (p<0.05 for two groups). Premedication with intravenous dexmedetomidine provided equal levels of sedation and more evident analgesia compared with midazolam. In addition, dexmedetomidine prolonged sensory blockage of bupivacaine-induced spinal anesthesia.