Insights from biochemical reconstitution into the architecture of human kinetochores

John R. Weir,Alex C. Faesen,Kerstin Klare,Arsen Petrovic,Federica Basilico,Josef Fischböck,Satyakrishna Pentakota,Jenny Keller,Marion E. Pesenti,Dongqing Pan,Doro Vogt,Sabine Wohlgemuth,Franz Herzog,Andrea Musacchio

Insights from biochemical reconstitution into the architecture of human kinetochores

2016

John R. Weir
Alex C. Faesen
Kerstin Klare
Arsen Petrovic
Federica Basilico
Josef Fischböck
Satyakrishna Pentakota
Jenny Keller
Marion E. Pesenti
Dongqing Pan
Doro Vogt
Sabine Wohlgemuth
Franz Herzog
Andrea Musacchio

Biochemical reconstitution of a synthetic human kinetochore with 21 protein subunits and centromeric nucleosomal DNA unveils fundamental principles of kinetochore organization and function.

Keywords:

Nucleosome
DNA
Mitosis
Kinetochore
Synthetic biology
Protein subunit
Cell biology
Kinetochore organization
Biology
Centromere
Microtubule
Spindle apparatus
Chromatin

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