Insulin resistance surrogates predict hypertension plus hyperuricemia.

OBJECTIVE To compare the association of hypertension plus hyperuricemia with four insulin resistance surrogates, including glucose and triglycerides (TyG index), TyG index with BMI (TyG-BMI), the ratio of triglycerides divided by HDL-C (TG/HDL-C), and a novel non-insulin-based fasting score (METS-IR). METHODS Data from a cross-sectional epidemiological study enrolling a representative population sample aged ≥65 years were used to calculate the four indexes. The association with hypertension plus hyperuricemia and insulin resistance surrogates was examined with multinomial logistic regression and receiver operating characteristic. RESULTS A total of 4,352 participants were included, including 93 (2.1%) patients with hyperuricemia alone, 2,875 (66.1%) with hypertension alone, and 587 (13.5%) with hypertension plus hyperuricemia. Multiple-logistic regression showed that TyG index, TyG-BMI, TG/HDL, and METS-IR were all significantly correlated with hyperuricemia, hypertension, and hypertension plus hyperuricemia. Compared with the lowest quartile, the ORs (95% CI) of the highest quartile of the four indicators for hypertension plus hyperuricemia were TyG index: 6.39 (4.17-9.78); TyG-BMI: 8.54 (5.58-13.09); TG/HDL-C: 7.21 (4.72-11.01); METS-IR: 9.30 (6.00-14.43), respectively. TyG-BMI and METS-IR had moderate discriminative abilities for hypertension plus hyperuricemia and the AUC values were 0.72 (0.70-0.74) and 0.73 (0.70-0.75). CONCLUSIONS Our study suggested that TyG index, TyG-BMI, TG/HDL-C, METS-IR had a significant correlation with hypertension plus hyperuricemia, and TyG-BMI and METS-IR had discriminative abilities for hypertension plus hyperuricemia.