A contemporary series of patients undergoing open debridement for necrotizing pancreatitis

Abstract Background For patients with acute pancreatitis complicated by infected necrosis, minimally invasive techniques have taken hold without substantial comparison with open surgery. We present a contemporary series of open necrosectomies as a benchmark for newer techniques. Methods Using a prospective database, we retrospectively identified consecutive patients undergoing debridement for necrotizing pancreatitis (2006 to 2009). The primary endpoint was in-hospital mortality. Results Sixty-eight patients underwent debridement for pancreatic/peripancreatic necrosis. In-hospital mortality was 8.8% ( n = 6). Infection ( n = 43, 63%) and failure-to-thrive ( n = 13, 19%) comprised the most common indications for necrosectomy. The false negative rate (FNR) for infection of percutaneous aspirate was 20.0%. Older age ( P = .02), Acute Physiology and Chronic Health Evaluation II score upon admission ( P = .03) or preoperatively ( P P = .01), and postoperative organ failure ( P = .03) were associated with mortality. Conclusions Open debridement for necrotizing pancreatitis results in a low mortality, providing a useful comparator for other interventions. Given the high FNR of percutaneous aspirate, debridement should not be predicated on proven infection.