Inhibitory Regulation by microRNAs and Circular RNAs

The microRNAs are responsible of a general post-transcriptional inhibitory activity partly unspecific due firstly to a possible direct negative action during translation by hybridizing tRNAs, and secondly to the large number of their putative targets. Recently a second regulation layer has been discovered involving both proteins as microRNA transcription factors and circular RNAs as microRNA inhibitors (“miRs sponges”). We will show the existence of circuits inside the role of miR-7 in the regulation of the spermatozoa morphogenesis.