Drug Eruptions From Anticonvulsant Drugs: Observations on Drug-Induced Lesions That Were Fixed and Lupus-Erythematosus-Like, and on Cross-Reactivity Between Several Drugs Involved

Two cases are reported of cutaneous and systemic reactions due to hydantoin type drugs and phenobarbital. The manifestations in part were characteristic for a fixed drug eruption and in part for a subacute lupus-erythematosus-like syndrome. Cross-sensitization among a number of hydantoin type drugs and phenobarbital was demonstrated.