Triterpenes from Acanthopanax sessiliflorus fruits and their antiplatelet aggregation activities.

One new triterpenoid saponin and two lupane-derived triterpenes were isolated from ACANTHOPANAX SESSILIFLORUS fruits. The structures of the two new compounds were elucidated as 3- O-[( α- L-arabinopyranosyl)-(1 → 2)]-[ β- D-glucuronopyranosyl-6- O-methyl ester]-olean-12-ene-28-olic acid ( 1) and (1 R,11 α,22 α)-1,4-epoxy-11,22-hydroxy-3,4-secolupane-20(30)-ene-3,28-dioic acid ( 3) on the basis of spectral analysis, including MS, 1 H-NMR, 13 C-NMR, DEPT, HMBC, HMQC and NOESY. The structure of the other new natural product was elucidated as (1 R,11 α)-1,4-epoxy-11-hydroxy-3,4-secolupane-20(30)-ene-3,28-dioic acid ( 2). All these compounds showed antiplatelet aggregation activity on ADP-induced platelet aggregation.