Worsening of Pre-Existing Psychiatric Conditions During the COVID-19 Pandemic

This study anonymously examined 2,734 psychiatric patients worldwide for worsening of their pre-existing psychiatric condition during the COVID-19 pandemic. Valid responses mainly from 12 featured countries indicated self-reported worsening of psychiatric conditions in 2/3rd of the patients assessed that was validated through their significantly higher scores on scales for general psychological disturbance, post-traumatic stress disorder, and depression. Female gender, feeling no control of the situation and reporting dissatisfaction with the response of the state during the COVID-19 pandemic, and reduced interaction with family and friends increased the worsening of pre-existing psychiatric conditions, whereas optimism, ability to share concerns with family and friends and using social media like usual were associated with less worsening. An independent clinical investigation from the USA confirmed worsening of psychiatric conditions during the COVID-19 pandemic based on identification of new symptoms that necessiated clinical interventions such as dose adjustment or starting new medications in more than half of the patients. Funding Statement: The authors worked voluntarily for this project and have no funding source to disclose. AJ is supported by an International Research Agenda (MAB) grant by Foundation for Polish Science (FNP). Declaration of Interests: The authors declare no competing interests. Ethics Approval Statement: The study procedures were reviewed and approved by University of Zurich Research Office for Scientific Integrity and Cantonal Ethics Commission for the canton of Zurich (Switzerland; Appendix 3), Nencki Institute of Experimental Biology, Warsaw (Poland; Appendix 4), and the Faculty of Medicine, University of Tuzla, Tuzla (Bosnia and Herzegovina; Appendix 5).