Desoxyribonucleic Acid (DNA)-Bentonite Flocculation Test for Lupus Erythematosus

Summary(1) The test is conducted by adding a suspension of bentonite particles previously coated with desoxyribonucleic acid (DNA) to heat inactivated serum dilutions. (2) Flocculation test showed agreement with L. E. cell test in 8 cases of lupus erythematosus. (3) L. E. cell test appeared to be more sensitive than flocculation test in cases in remission. (4) The flocculation test appeared to be more specific. In 6 selected cases of rheumatoid arthritis, the L. E. cell test was positive; on the contrary, the DNA-bentonite flocculation tests were negative.