PHOSPHATIDYLINOSITOL-3 KINASE (PI3-KINASE) HAS A PROTECTIVE ROLE IN ANGIOTENSIN II-INDUCED PODOCYTE INJURY

Objective:PI3-kinase has distinct roles in cellular processes spanning from metabolism to cell motility and survival. Angiotensin II (Ang II) promotes the development and progression of proteinuria and renal diseases and induces podocyte apoptosis. CD2-associated protein (CD2AP) in podocytes, anchor