Short Communication Proteome alterations in human host cells infected with coxsackievirus B3

Coxsackievirus B3 (CVB3) is a common factor in human myocarditis. The interplay betweenhost factors and virus components is crucial for the fate of the infected cells. Despite that, hostprotein responses, which characterize CVB3-induced diseases, have not yet been determined indetail. Toinvestigate thenature of modifiedprotein patternsin infectedhumancells comparedwithuninfected cells, two-dimensional gel electrophoresis in combination with matrix-assisted laserdesorption/ionization-mass spectrometry were used. The regulated proteins, e.g. nucleophosmin(nucleolar protein B23), lamin, the RNA-binding protein UNR and the p38 mitogen-activatedproteinkinase,weresortedaccordingtotheirfunctionalgroupsandinterpretedinthecontextofthemyocarditis process.