Etat des lieux sur la tolérance du traitement de la tuberculose multi résistante (Burkina Faso)

Objectives: Estimate the tolerance of antituberculous drugs prescribed in the treatment of the resistant multi-tuberculosis at the patients followed in the service of Pneumology of the University hospital Yalgado Ouedraogo (UH YO). Patients and methods: It was about a retrospective and forward-looking longitudinal investigation. The files of the patients allowed to inform the questionnaire for the retrospective phase (2010-2011), the follow-up of the patients during the forward-looking phase (2011-2013) allowed the data collection. All the patients under antituberculous treatment of 2nd line between January 1st, 2010 and the August 31st, 2013were included. Results: all in all 71 cases of resistant multi-tuberculosis (RMT) were recruited. The sex-ratio was 3.4. The age bracket from 30 to 39 was the most represented (39,4 %). A notion of contage tubercular was found to 18 (25.3 %) patients. All the patient RMT had histories of treatment including aminoside of duration 2-month-old superior. The tolerance of the treatment was brought back at 57 patient's, prevailing at 30 in 39 years and at the co-infected subjects Tuberculosis / HIV. The neurological infringements (47.9 %) and psychiatric (47.9 %) were the most represented. The affected hallway and of the cochlear was 42.3 % with 18.3 % of total deafness. Therapeutic modifications were made further to the occurrence of intolerant side effects, even grave and a symptomatic treatment was made in certain cases. Conclusion: The intolerance of the antituberculous treatment of the second line is real one obsession for the clinician. Shorter diets would avoid certainly therapeutic modifications at the origin of occurrence of failures.