Clinical observation of Argatroban on thrombotic syndrome in 4 cases with heparin-induced thrombocytopenia

Objective To observe the anticoagulation of Argatroban on 4 cases with heparin-induced thrombocytopenia(HIT).Methods A positive diagnosis for venous thromboembolism and anticoagulation contraindications in 202 cases was enrolled.All of them were treated with low molecular weight heparin(LMWH)and/or unfractionated heparin(UFH).The peripheral blood cells and coagulation indexes were examined regularly to determine if the adverse reaction of thrombocytopenia occured.Four cases of heparin-induced thrombocytopenia stopped using heparin,while was treated with Argatroban(20 mg/d)instead for 3-7 d.Results The platelet recovered to the basic level after withdrawing heparin and initiating Argatroban,the thrombotic syndrome did not appear and the lower limb swelling in clinical symptoms could be relieved immediately.Conclusion Argatroban could effectively replace heparin to prevent the secondary thrombosis with HIT.