Effect of Madhuriktha on Dexamathasone and Fructose Induced InsulinResistance in Rats

Madhuriktha a polyherbal formulation has been examined to investigate the effect of insulin resistance induced by dexamethasone and fructose. Dexamethasone was administered at a dose of 10 mg/kg S.C for 10 days and fructose was feed as 10% w/v aqueous solution in feeding bottles for 20 days. At end of the experimental period, body weight changes and serum biochemical parameters like glucose, insulin, triglycerides, cholesterol HDL and LDL levels were estimated. Madhuriktha at 200mg/kg and 400 mg/kg showed significant effect by normalizing the rise in serum glucose, insulin, triglyceride, cholesterol, HDL and LDL levels and improved the body weights.