Seroprevalence of antibodies against the three serotypes of poliovirus and IPV vaccine response in adult solid organ transplant candidates
2018
Objectives: To assess the prevalence of protective antibody titers to polioviruses in adults candidates for
solid organ transplant (SOT), and to assess the immunogenic response to inactivated polio vaccine in this
population.
Methods: The study included SOT candidates referred to Immunization Reference Centre of Evandro
Chagas National Institute of Infectious Diseases from March 2013 to January 2016. It was conducted in
2 phases. The first one, a cross-sectional seroprevalence study, followed by an uncontrolled analysis of
vaccine response among patients without protective antibody titers at baseline. Antibody titers to
poliomyelitis were determined by microneutralization assay.
Results: Among 206 SOT candidates included, 156 (76%) had protective antibody titers to all poliovirus
serotypes (95% CI: 70–81%). Proven history of oral vaccination in childhood was not associated with
higher seroprevalence of protective antibody. In 97% of individuals without protective antibody titers
at baseline, there was adequate vaccine response with one dose of inactivated polio vaccine.
Conclusions: A relevant proportion of adult candidates for SOT does not have protective titers of antibodies
to one or more poliovirus serotype. One dose of inactivated vaccine elicited protective antibody titers
in 97% of these subjects and should be routinely prescribed prior to SOT.
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