CCL-2 is a KIT D816V-dependent Modulator of the Bone Marrow Microenvironment in Systemic Mastocytosis

Systemic mastocytosis (SM) is characterized by abnormal accumulation of neoplastic mast cells harboring the activating KIT mutation D816V in the bone marrow and other internal organs. As found in other myeloproliferative neoplasms, increased production of profibrogenic and angiogenic cytokines and