Piper Betle Leaves Extract Works Synergistically with 5-Fluorouracil inControlling Colorectal Cancer Cell Growth

Background: Piper betle (PB) leaves (daun sirih in Malay language) extract has been demonstrated to have anticarcinogenic activities in the experimental systems. It has been found the PB leaves extract could enhance the cytotoxic effect of other anticancer drugs in cancer cells. The aim of this study is to investigate the combination effect of PB and 5-fluorouracil (5-FU) in enhancing the cytotoxic potential using colon cancer cell lines.