Compositions and methods for using antibodies to sclerostin

An isolated or portion antibody binding to antigens thereof, wherein the antibody or binding portion antigen thereof specifically binds polypeptides of sclerostin and comprises: (a) a variable region CDR1 heavy chain comprising an amino acid sequence that It consists of SEQ ID NO: 4; (B) a variable heavy chain region CDR2 comprising an amino acid sequence consisting of SEQ ID NO: 15; (C) a variable region CDR3 heavy chain comprising an amino acid sequence consisting of SEQ ID NO: 26; (D) a variable light chain region CDR1 comprising an amino acid sequence consisting of SEQ ID NO: 37; (E) a light chain variable region CDR2 comprising an amino acid sequence consisting of SEQ ID NO: 48; and (f) a variable region CDR3 light chain comprising an amino acid sequence consisting of SEQ ID NO: 59