Assessment of Physical Stability of an Antibody Drug Conjugate by Higher Order Structure Analysis: Impact of Thiol- Maleimide Chemistry

Jianxin Guo,Sandeep Kumar,Amarnauth Shastrie Prashad,Jason A. Starkey,Satish K. Singh

Assessment of Physical Stability of an Antibody Drug Conjugate by Higher Order Structure Analysis: Impact of Thiol- Maleimide Chemistry

2014

Jianxin Guo
Sandeep Kumar
Amarnauth Shastrie Prashad
Jason A. Starkey
Satish K. Singh

Purpose To provide a systematic biophysical approach towards a better understanding of impact of conjugation chemistry on higher order structure and physical stability of an antibody drug conjugate (ADC).

Keywords:

Higher Order Structure
Conjugated system
Thiol
Molecular model
Maleimide
Antibody-drug conjugate
Chemistry
Biochemistry
physical stability
pharmacology toxicology

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