Ziconotide Inhibits KCL-Induced Increase in Intracellular Calcium in Rat Sensory Neurons: A Peripheral Mechanism of Analgesic Action

Objective: Ziconotide, a novel non-opioid intrathecal analgesic agent with higher anal - gesic activity than morphine, has been recently approved for the treatment of severe and cronic pain. However, the exact cellular mechanism of the analgesic effects of ziconotide is not well documented. The aim of this study was to investigate the effects of ziconotide on KCl-induced intracellular calcium ((Ca