Effect of Shenxiong glucose injection on platelet reactivity during aspirin treatment in patients with acute ischemic stroke

Objective To investigate the effect of Shenxiong glucose injection on platelet reactivity during aspirin treatment in patients with acute ischemic stroke. Methods A total of 263 patients with acute ischemic stroke admitted to 12 hospitals from January 2014 to December 2016 were enrolled prospectively. They were randomly divided into aspirin group and aspirin+ Shenxiong glucose injection group. The changes of platelet maximum aggregation rate induced by 4 platelet aggregating agents (arachidonic acid, adenosine diphosphate, collagen and platelet activating factor) were detected before and after the treatment. Results There were no significant differences in the demographic data and baseline clinical characteristics between the aspirin group (n=132) and the Shenxiong glucose injection+ aspirin group (n=131). At baseline, the maximum aggregation rate of platelet induced by arachidonic acid and platelet activating factor in Shenxiong glucose injection+ aspirin group was significantly higher than that in the aspirin group (all P<0.05). On the 6th day after treatment, the maximum aggregation rate of platelets induced by the 4 aggregating agents in the Shenxiong glucose injection+ aspirin group was significantly lower than that in the aspirin group (all P<0.001). Conclusion Shenxiong glucose injection had a significant inhibitory effect on platelet reactivity during aspirin treatment in patients with acute ischemic stroke. Key words: Stroke; Brain Ischemia; Shenxiong Glucose Injection; Aspirin; Platelet Aggregation; Platelet Function Tests