[Research of the relationship of ubiquinone and beclin-1 and liver mitochondria].

Objective To study whether CO-Q10 can protect liver injury caused by acute on chronic liver failure(ACLF) by autophagy.Methods Rats were separated into three groups:control group,acute on chronic liver failure (ACLF) and intervenient group,liver tissues were observed by optical microscopy and electron microscopy.The levels of Beclin-1 expression were determined by real-time PCR.And Western Blot.Results Areas of necrosis detected in intervenient group were alleviated than in ACLF significantly.Most mitochondrias had been degradated in ACLF group while alive in intervenient group.Real-time PCR and Western Blot revealed level of beclin-1 in ACLF was lower than control and intervenient group.Conclusion lntervenient group may ameliorate rat liver injury by promoting autophagy. Key words: Liver failure ;  Microscopy, electrol ;  Polymenase chain reaction