Vinorelbine, cisplatin, and continuous infusion of 5-fluorouracil (ViFuP regimen) in carcinoma of unknown primary

e20682 Background: Carcinoma of unknown primary (CUP) is rarely encountered in clinical practice, 3–5% of all new cancers, and several types of chemotherapy regimens have not yielded satisfactory results. Methods: We evaluated feasibility and efficacy of combined vinorelbine 20 mg (V) on day 1 and 3, continuous infusion 5-fluorouracil (5-Fu) 200 mg/m2 days 1–21 and cisplatin (C) 60 mg/ m2 day 1, 21 (ViFuP regimen) therapy in patients (pts) with CUP. Each course was repeated every 21 days for up to six cycles, followed by 5-FU continuous infusion in case of response or clinical benefit. Results: Twenty-six consecutive pts with CUP were enrolled in the study, 14 females and 12 males. Median age was 58 years (range 35–72). All pts are evaluable for response and toxicity. All pts were chemotherapy-naive with the exception of 2 who had received prior 5-Fu and folinic acid (1 pt) and paclitaxel and adriamicin (1 pt). Objective responses were observed in 27% [6 PR (23%), 1 CR (4%)], while SD in 35% (9) of the pt...