Comparison of serum heat shock protein 60 levels in patients with periodontal disease and cardiovascular disease

Self-antigens such as heat shock protein 60 (HSP 60) has been implicated recently in the pathogenesis of both periodontal and cardiovascular disease. There are some evidence regarding HSP 60 and HSP 70 in circulation following periodontal disease and cardiovascular disease and its possible relationship. Forty-five peripheral blood samples were collected from two groups of patients. Group I - periodontal disease and group II - cardiovascular disease. Serum was used to detect and compare HSP 60 in both the groups by enzyme-linked immune sorbent assay (ELISA) technique. Statistical analysis was done student t test. Serum HSP 60 significantly increases in cardiovascular disease compared to periodontal disease.