Отклонения в психическом развитии потомства крыс с экспериментальной преэклампсией и их коррекция новым производным гамма-аминомасляной кислоты

The aim of investigation was to study the effect of a gamma-aminobutyric acid´s derivative – a compound RGPU-242 – on the mental development of the rat´s offspring with experimental preeclampsia. Famels’s preeclampsia was modeled  by  replacing  the  drinking  water  of 1.8%  sodium  chloride solution from 7th to the 21th day of gestation. Locomotion, indicative and emotional activity and cognitive functions in progeny were recorded on “Open field”, “One-way step-down inhibitory (“passive”) avoidance”, “Elevated plus maze” and “Test of extrapolative escape” tests in different periods of postnatal development. Found that the compound RGPU-242 has gravidoprotective effect, improves formation and development of mental functions in the offspring.