Synthesis and Antibacterial Activities of New Carbapenems Having a Proline Reverse Amide Moiety at the C‐2 Position

The synthesis of new 1β-methyicarbapenems (1a-1) having a proline reverse amide moiety at the C-2 position and their in vitro antibacterial activities are described. The compounds were evaluated by the Muelier-Hinton agar dilution method and compared with meropenem as control. Aliphatic amides (1a-b) are found to show greater antibacterial activity than aromatic amides (1i-l). Moreover, C-2 free anuno compound (1m) reveals greater activity than any otner amide compounds (1a-l).