The Evaluation of Vitamin D Deficiency in Patients with Nasal Polyposis

Background: Despite performing surgical treatment, chronic rhinosinusitis coexisting with polyposis has recurrent episodes. Considering the strong association between nasal polyposis and asthma, the role of Vitamin D deficiency has been demonstrated in most of the asthma attacks. Purpose :To investigate the serum level of 25-hydroxy vitamin D in chronic rhino sinusitis among the patients with and without nasal polyposis. Methods :In this cross-sectional study, we evaluated the vitamin D deficiency in 38 patients with nasal polyposis and 38 control patients, using immunoassay examination.  Data of the two groups were compared and analyzed via SPSS software version 18. The significant level was considered as less than 0.05. Results: We found severe vitamin D deficiency in 47.4% of the polyposis patients, while this rate decreased to13.3% in the control group (p=0.004). Based on the age group classification, there was no statistically significant difference in terms of the vitamin D deficiency between the polyposis patients and control group (p=0.66).   Conclusion: Vitamin D deficiency can be associated with the prevalence of nasal polyposis in the patients affected by chronic rhinosinusitis. Further studies can prove the essential role of vitamin D in pathogenesis of nasal polyposis.