Non paraneoplastic immune-mediated calcium channel chorea

Antibodies to the N-type voltage-gated calcium channel have rarely been reported in association with chorea. Prior reported cases have been either paraneoplastic in nature or presented in the setting of other concurrent antibody elevations. Moreover, the identified studies showed only mild elevation of calcium channel antibodies. We present a case of chorea in association with an isolated serum elevation in N-type calcium channel antibodies and clinical improvement with intravenous immunoglobulin.