Superoxide dismutase mimetics. Part 2: synthesis and structure–Activity relationship of glyoxylate- and glyoxamide-Derived metalloporphyrins

Abstract Novel glyoxylate- and glyoxamide-derived metalloporphyrins 26 – 58 were synthesized and evaluated as potential superoxide dismutase (SOD) mimetics. Relative to previously studied MnTBAP analogues, the glyoxylate-derived metalloporphyrins 32 , 39 , and 54 and glyoxamide-derived metalloporphyrin 49 , exhibited enhanced activity in the SOD assay and the majority of the analogues in the current series showed enhanced inhibition of lipid peroxidation and catalase activity.