7-DIALKYLAMINOMETHYL-2,4,5-TRIMETYL- AND 2,4,5-TRIMETHYL-7-PHENYLIMINOMETHYL-1,2,3,4-TETRAHYDROPYRROLO[1,2- c ]PYRIMIDINES
2013
The Mannich aminoalkylation of 2,4,5-trimethyl-1,2,3,4-tetrahydropyrrolo[1,2- c ]pyrimidine and condensation of its 7-formyl derivative with aniline have been studied. 7-Morpholinomethyl- and 7-(N-methylpiperazinylmethyl)-substituted derivatives have been isolated. 7-Dimethylaminomethyl- and 7-phenyliminomethyl-substituted derivatives of tetrahydropyrrolo[1,2- c ]pyrimidines are easily cleaved in the process of chromatographic isolation. Authors: A. V. Varlamov, T. N. Borisova, E. A. Sorokina, A. I. Chernyshev, and A. N. Levov. English Translation in Chemistry of Heterocyclic Compounds , 1999, 35 (12), pp 1455-1458 http://link.springer.com/article/10.1007/BF02251822
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