Potencial anti-apoptótico de p38 en cáncer de próstataAnti-apoptotic potencial role of p38 in prostate cancer

Introduction TNF-α transduction pathway in prostate cancer seems to be diverted towards p38 activation. P38 may protect prostate tumoral cells from TNF-α apoptosis induced. The aim of this study was study the role of p38 in vivo (were evaluated some p38 downstream factors), as well as in vitro (in prostatic tumoral cell lines, LNCaP and PC3, pre-treated with TNF-α).