The preparation method of 4-[(the chloro-2-pyrimidyl of 4-) is amino] cyanophenyl

The invention discloses the preparation method of a kind of 4-[(the chloro-2-pyrimidyl of 4-) is amino] cyanophenyl, this preparation method uses N, N ,-dimethylamino acrylate and N-(4-Cyanophenyl)guanidine are reacted and are generated II, then generate object product with the chlorination of the phosphorus oxychloride when magnitude.This preparation method can improve product yield and quality, reduces costs, easy and simple to handle, is the synthetic route of the rilpivirine intermediate of applicable suitability for industrialized production.