Cerebroprotective properties of ademol in traumatic brain injury

The goal of the work – to compare the effect of adamantine 1-adamantylethyloxy-3-morpholino-2-propanol hydrochloride (Ademol) derivative and magnesium sulfate on mnestic function and neurological deficit in an experimental model of traumatic brain injury.Material and methods. The therapeutic effect of Ademol on modulated traumatic brain injury was evaluated with the use of doses of 1, 2 and 4 mg / kg intravenously. Pseudoperated animals received 0.9% NaCl solution based on the volume of the most effective dose of Ademol. As a drug for the control group we used 0.9% NaCl solution at a dose of 2 ml / kg i/v and in the same mode. Neurological deficit in rats with traumatic brain injury was evaluated on the first day and at the end of the acute period (on the eighth day) on the stroke-index C.P. McGrow scale. The animals' ability to learn and remember the aversive stimulus was examined in conditional reaction of passive avoidance test. The technique is based on the innate instinct of rats to a limited darkened space. The conservation of the conditioned responce was checked in a day by the change of the latent time of rat entry to the dark compartment. We also noted the number of animals that tried to enter the dark compartment but did not complete the attempt.Results. While analyzing the effect of course therapy with Ademol solution on the degree of de-escalation of neurological deficiency, it can be noted that by this property the investigated drug outweighed the magnesium sulfate solution on the first day of application by 24% and on the eighth day by 30% (p<0.05). Regarding the restoration of mnestic functions in traumatic brain injury, the eight-day treatment of rats with magnesium sulfate solution somewhat improved memory, but was inferior to the efficacy of Ademol, which approximated the results of the conditional reaction of passive avoidance test to the results of pseudoperated animals.Conclusions. The results of the experimental study make it possible to confirm the lack of reliable effectiveness of using magnesium sulfate in the correction of neurological deficiency at traumatic brain injury in rats. Ademol, unlike the magnesium sulfate solution, contributed to the reduction of the severity of neurological disorders, which was accompanied by an improvement of mnestic functions in animals on the eighth day of traumatic brain injury.