Biomarkers for AKI
2013
markdownabstract__Abstract__
Acute kidney injury (AKI) represents an abrupt decrease in renal function that leads to
accumulation of nitrogenous waste products such as blood urea nitrogen and creatinine.
AKI refers to a complex disorder that comprises multiple causative factors (ischemic,
nephrotoxic and septic components with overlapping pathofysiological mechanisms)
and occurs in a variety of settings with numerous clinical manifestations that range from
minimal elevation in serum creatinine (SCr) to anuric renal failure. In the critical care
setting, AKI affects 5-25% of patients and accounts for an overall mortality rate of 50-
80%] Once established the treatment of AKI is largely supportive, unsatisfactory and
associated with a poor prognosis. Furthermore, AKI is independently associated with
an increased risk of death and with a prolonged length of stay. Even small changes
in SCr can affect outcome in severely ill patients with multiple-organ dysfunction. Progressive insight in pathofysiological mechanisms of AKI has shown that tubule
cell necrosis is rarely encountered in human acute renal failure, indeed the disparity
between the severe impairment of renal function and the relatively subtle histological
changes in AKI have been bothersome.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI