Determination of antimalarials drugs by liquid chromatography in pharmaceutical formulations and human blood: a review

Malaria is a life-threatening disease being treated by oral medication, this treatment is the best way to reduce morbidity, mortality, prevent disease progression to the most severe form, lower the transmission of the disease and hinder the appearance of strains resistant to antimalarials. According to the World Health Organization, the most common antimalarials drugs are chloroquine, primaquine, mefloquine, lumefantrine, artemether, and artesunate in single dosage form or fixed-dose combination. Within this context, the present review aims to show the evolution of different analytical methods that have been applied to the determinations of these antimalarial drugs by liquid chromatography in pharmaceutical formulations and human plasma in the last 10 years, along with statistical analyses of the methods.