Highly regioselective dehexanoylation in fully hexanoylated flavonoids

Abstract Highly selective removal of the 7- O -hexanoyl group in fully hexanoylated flavones, isoflavones, flavanone, and flavonol was achieved under mild conditions using K 2 CO 3 in a 1:1 mixture of CH 3 OH–CH 2 Cl 2 . The resulting 7-OH flavonoids are valuable intermediates for the synthesis of flavonoid 7- O -glycosides via phase-transfer-catalyzed (PTC) glycosylation.