Abstract 14190: Longer Time in Therapeutic Blood Pressure Range Protects Against Major Adverse Cardiovascular Events and All-Cause Mortality in Patients With Hypertension: A Post-Hoc Analysis of SPRINT

Introduction: Intensive blood pressure (BP) lowering reduces the risk of major adverse cardiovascular events (MACE) in high risk patients. However, BP varies over the short- and long-terms and the minimum proportion of time at or below BP goal necessary for MACE reduction is unknown. Hypothesis: Higher time in therapeutic blood pressure range (TTBPR) is associated with lower all-cause and cardiovascular mortality and major adverse cardiovascular events in patients with hypertension. Methods: We included subjects from the SPRINT (A Randomized Trial of Intensive versus Standard Blood-Pressure Control) with ≥ 2 BP readings (n=9248 [99% of all subjects]). TTR was calculated with the linear interpolation method using a BP goal of 110-130 mm Hg. Patients were categorized into 4 TTBPR groups (0-25%, 26%-50%, 51%-75%, 76%-100%). Cox proportional hazards regression adjusted for age, gender and ethnicity was used to determine the relationship of TTBPR group to MACE with 0-25% as the reference group. Results: Mean a...