The effect of hyperbilirubinemia on pain intesity in patients with pancreatobiliaric cancer during perioperative period

The aim was to assess the effect of hyperbilirubinemia on the severity of pain syndrome in patients with pancreatobiliary cancer during perioperative period. Materials and methods. The results of surgical treatment of 218 patients with pancreatobiliary cancer complicated by the development of mechanical jaundice syndrome, who underwent pancreatoduodenal resection, were analyzed. The severity of pain was assessed on a visual-analog scale, as well as subscales of questionnaires EORTC QLQ-C30 and SF-36. Results. At the time of admission to the hospital the initial level of total bilirubin was 274.3 ± 5.9 μmol/L, direct - 211.2 ± 2.2 μmol/L, indirect – 63.4 ± 2.6 μmol/L. The intensity of pain syndrome on admission was 4.9 ± 0.4 points. In the early, late and late postoperative period the intensity of pain decreased, respectively, from 6.4 ± 0.3  to 2.8 ± 0.4 points. Conclusions. A strong positive correlation between the intensity of pain syndrome and the level of cholemia was determined (r = 0.74).