Development of a planar microelectrode array offering long-term, high-resolution neuronal recordings

All nervous system functions, ranging from simple reflexes to learning and memory, rely on networks of interconnected brain cells called neurons, which initiate and convey electrical information. Monitoring neuronal activities of a large neuronal ensemble, non-invasively and over an extended time period, is pivotal for understanding all brain functions. A variety of neuro-electronic interfaces now allow monitoring of neuronal and ion channel activities. These neuronal monitoring devices are however limited vis-a-vis their efficacy, fidelity and longer-term recording capabilities. Here we report on a novel microelectrode array technology that allows for the detection and characterization of neural activity from individual cells and networks, over long periods of time and with a higher signal-to-noise ratio than commercially available devices.