CC-1065 analogs substituted and their conjugates

A compound of formula (I) or (II): or a salt, hydrate or solvate pharmaceutically acceptable thereof, in the queR1 is selected from halogen, azide (N3), carboxylate [OC (O) Rn] carbonate [OC ( O) ORN] carbamate [OC (O) N (Rn) Rn '] and OS (O) 2RO, in which Rn and Rn' are independently selected from C1-6 alkyl and heteroalkyl and substituted C1-6opcionalmente wherein R ° is selected from C1-6 perhaloalkyl and C1-6, benzyl or substituted alkyl feniloopcionalmente; R2 is selected from H, N3, NO2, NO, CF3, CN, C (O) NH2, C (O) H, C (O) OH, halogen, Rb, SRb, S (O) Ra, S (O) 2Ra, S (O) ORa, S (O) 2OR , OS (O) Ra, OS (O) 2 R, OS (O) ORa, OS (O) 2OR , ORb, N (R) R, + N (Rb ) (Rc) Rd, P (O) (ORa) (ORa), OP (O) (ORa) (ORa), SiRaRa'Ra ", C (O) Ra, C (O) ORa, C (O ) N (Ra) Ra ', OC (O) Ra, OC (O) ORa, OC (O) N (Ra) Ra', N (Ra) C (O) R ', N (Ra) C (O) ORa 'and N (Ra) C (O) N (Ra') Ra ', where Ra, Ra' and Ra "15 independently selected from H and C1-3alkyl or C1-3 heteroalkyl optionally substituted and R , Rc and Rd are independently selected from C1-3 alkyl and C1-3 heteroalkyl, optionally substituted; R3, R3 ', R4 and R4' are independently selected from H and C1-3alkyl optionally substituted, wherein twoor more of R2, R3, R3 ', R4 and R4' are optionally linked by one or more bonds to form one or more carbociclosy / or optionally substituted heterocycles and / or R3 + R3 'and / or R4 + R4' are so independent> = O,> = S,> = NOR 18 20 or> = NR18, R18 being selected from H and alkyl Optionally substituted C1-3. X2 is selected from O, C (R14) (R14 ') and NR14' wherein R14 is selected from H and C 1-8 alkyl or C 1-8 acyl opcionalmentesustituidos and wherein R14 'is absent or is selected from H and C1-8 alkyl or C1-8 acyl optionally substituted; R5 and R5 'are independently selected from OH, SH, NH2, N3, NO2, NO, CF3, CN, C (O) NH2, C (O) H , C (O) OH, halogen, Rc, SRc, S (O) Re, S (O) 2R, S (O) ORe, S (O) 2ORe, OS (O) Re, OS (O) 2R, OS (O) ORe, OS (O) 2ORe, e, NHR e, N (Re) Rf, -N (Re) (Rf) Rg, P (O) (OR e) (OR f), OP (O) (OR e) ( ORf), SiReRfRg, C (O) Re, C (O) ORe, C (O) N (Re) Rf, OC (O) Re, OC (O) OR e, OC (O) N (Re) Rf, N (Re) C (O) Rf, N (Re) C (O) ORf and N (Re) C (O) N (Rf) Rg, wherein Re, Rf, and Rg is seleccionande independently from H and alkyl C1-3, C1-3 heteroalkyl, C3 or C1-3 heterocycloalkyl opcionalmentesustituidos provided that Re is not H when R5 is Rc, wherein two or more of Re, Rf and Rg together optionally poruno or more bonds to form one or more carbocycles and / or heterocycles optionally substituted, and R6, R6 ' , R7 and R7 'are independently selected from H, OH, SH, NH2, N3, NO2, NO, CF3, CN, C (O) NH2, C (O) H, C (O) OH, halogen, Re ', SRe', S (O) R ', S (O) 2R', S (O) ORe ', S (O) 2ORe', OS (O) R ', OS (O) 2R, S (O) e, OS (O) 2ORe ', ORe', NHR e ', N (R') Rf, + N (R ') (Rf) Rg', P (O) (OR e ') (ORf), OP (O) (ORe ') (ORf), SiRe'RfRg', C (O) R ', C (O) OR e', C (O) N (R ') Rf, OC (O) R', OC (O) ORe ', OC (O) N (R') Rf, N (Re) C (O) Rf, N (R ') C (O) ORf and N (R') C (O) N (Rf) Rg ', where Re ', Rf and Rg' seseleccionan independently H and C1-6 alkyl, C1-6 heteroalkyl, C3-7 cycloalkyl, C1-7 heterocycloalkyl, C6-12 aryl or C1-12 heteroaryl optionally substituted, wherein two or more of Re ', Rf and Rg' joined by one or masenlaces to form one or more carbocycles and / or heterocycles optionally substituted. and / or R5 + R5 'and / or R6 + R6', and / or R7 + R7 'are independently> = O,> = S,> = NOR 12 or> = NR12, being R12seleccionado of H and C1 -3 optionally substituted and / or R5 '+ R6' and / or R 6 '+ R 7', and / or R7 '+ R14' 40 are absent, which means that a double bond is present between losatomos carriers R5 ' and R6 'and / or R6' and R7 'and / or R7' and R14 'respectively, wherein two or more of R5, R5', R6, R6 ', R7, R7', R14, and R14 'optionally connected by links to form one or more carbocycles or one and / or heterociclosopcionalmente substituted; X1 is selected from O, S and NR13, wherein R13 is selected from H and optionally substituted C1-8 alkyl; X3 is selected from O, S and NR15, wherein R15 is selected 45 from H and C1-8 alkyl or C1-8 acyl opcionalmentesustituidos; or -X3- represents -X3a and X3b- wherein X3a, is connected to the carbon to which X4 is attached and is connected X3b alanillo phenyl ortho R10, wherein X3a is independently selected from H and C1 -8 aciloC1-8 or optionally substituted, and X 3b is selected from the same set of substituents R8; X4 is selected from N and CR16, wherein R16 is selected 50 from H and C1-8 acyl or C1-8 alkyl optionally substituted; X5 is selected from O, S and NR17, where R17 is selected from H and alkyl C1-8 or C1-8 acyl opcionalmentesustituidos;