Structure elucidation of two novel peptides from a mushroom-derived Streptomyces sp.

Bacterial-fungal interactions are present in numerous environments, including agriculture, food, and the human body, but in many cases, this relationship is not well understood. To investigate interactions between bacteria and fungi, we examined the metabolites produced by several bacterial strains isolated from a collection of mushrooms. One strain (Streptomyces sp. HrubLS-53), isolated from the mushroom Hymenochaete rubiginosa, was found to produce enterobactin and paenibactin, as well as two novel peptides. The novel structures were determined by NMR and MS, including a 13C-13C COSY of isotopically enriched compounds.